ABSTRACT
The Available Findings showed that morphia induce dysfunction of the ultrastructure of the nerve cells by direct injury to the mitochondria which are intimately linked with the energy and oxidation metabolism. Serious disorders of the respiratory function in nerve cells cause accumulation of incompletely oxidised products, impairment of intracellular homeostasis and reaction of other cell organelles which are not directly related to energy prodution. So, great increase of lysosmal enzymes activity occur that taking upon themselves the function of removal of semide-composition products and fatal cases cell autolysis. The features of cellular reaction to morphine showed unequal vulnerability of different types of neurones and selective sensitivity of various C.N.S. Formations